Effects of Exogenous Glutathione on Arsenic Distribution and NO Metabolism in Brain of Female Mice Exposed to Sodium Arsenite through Drinking Water 外源性谷胱甘肽对饮水砷暴露雌性小鼠脑砷形态及一氧化氮代谢的影响
Reproductive toxicity of sodium arsenite in male mice 亚砷酸钠对雄性小鼠的生殖毒性作用
Effects of Sodium Arsenite on Glutathione S-transferase and Its Genes Expression in Mice 亚砷酸钠对小鼠体内谷胱甘肽S-转移酶活力及其基因表达的影响
Experimental study of germ cell damage of male mice induced by sodium arsenite 亚砷酸钠对雄性小鼠生殖细胞损伤的实验研究
Objective: To investigate the different dose sodium arsenite ( NaAsO_2) on lymphocyte biological effect and function mechanism, and the antagonism effects of selenium in vitro. 目的:体外培养人外周血淋巴细胞,探讨不同浓度的亚砷酸钠(NaAsO2)对淋巴细胞的生物学效应及作用机制,并观察亚硒酸钠(Na2SeO3)对砷毒性的拮抗作用。
Effect of sodium arsenite to the level of twenty genes expression 砷对20个基因表达水平影响的研究
Objective: To study the combined effect and antitumor mechanism of sodium arsenite and HCPT on human gastric carcinoma cell lines BGC-823 and SGC-7901 in vitro. 目的:体外观察亚砷酸钠、羟基喜树碱对人胃癌细胞株BGC-823、SGC-7901的联合效应,并探讨其作用机制。
Comparison of Lactate Dehydrogenase Isoenzymes of Hepatic Injury Induced by Phosphorus, Sodium Arsenite and Carbon Tetrachloride 黄磷亚砷酸钠四氯化碳肝损害LDH同工酶的比较研究
Objective To investigate the relationship between the hormesis of proliferation and oxidative stress induced by sodium arsenite ( Na_2AsO_2) in human embryo lung fibroblasts ( HELF). 目的探讨亚砷酸钠(Na2AsO2)所致人胚肺成纤维细胞(HELF)增殖兴奋效应与氧化应激的关系。
The Antagonism and Mechanism of Selenium Compounds against Sodium Arsenite Inhibition Effect on Mitochondrial Enzymes in Rats 硒多糖、亚硒酸钠对大鼠肝线粒体酶的影响及其拮抗亚砷酸钠毒性作用的机理
Methods Induction of cell morphological transformation by the combination of nickel sulfate and sodium arsenite in Syrian hamster embryo ( SHE) cells was performed. 方法采用细胞灶法观察硫酸镍与亚砷酸钠联合致叙利亚地鼠胚胎(SHE)细胞的形态学转化作用。
Results Transformed foci were induced by both nickel sulfate and sodium arsenite alone, and their combination, and transformation frequencies were dose dependent. 结果硫酸镍、亚砷酸钠及硫酸镍与亚砷酸钠联合染毒三个组均有细胞转化灶形成,其形成率均呈现剂量依赖关系。
Objective To study the effects of sodium arsenite on gene expression related to growth and development and explored the molecular mechanism of arsenic effects using gene chips. 目的利用基因芯片技术研究亚砷酸钠对生长发育相关基因表达的影响,探讨砷的分子遗传学机制。
Conclusion Cigarette smoke solution with or without sodium arsenite decrease viability of cells and raise their oxidative stress, moreover, they have the interaction on oxidative stress of cells. 结论在本研究中香烟烟气溶液和亚砷酸钠单独作用或联合作用均能够降低大鼠淋巴细胞活力,增强细胞内的氧化应激反应,且两者对细胞内的氧化应激反应的影响存在交互作用。
Influence of Sodium Selenite and Sodium Arsenite on the Micronucleus Rate in Mouse Marrow Cells 亚硒酸钠和亚砷酸钠对小鼠骨髓细胞微核率的影响
Conclusion Sodium arsenite can inhibit the survival of lymphocytes of rats and the antioxidants can antagonize the cytotoxicity of arsenic. 结论亚砷酸钠可抑制淋巴细胞活力,抗氧化物可一定程度的拮抗三价砷的细胞毒性作用。
The Relationship between Lipid Peroxidation and Hormesis Caused by Sodium Arsenite 亚砷酸钠所致兴奋性效应与脂质过氧化的关系
Conclusions The sodium arsenite could affect the gene expression related to growth and development and it is shown that the molecular genetic mechanism of sodium arsenite is related to growth and development. 结论亚砷酸钠对生长发育相关基因表达有影响,初步揭示了砷对生长发育影响的分子遗传学机制。
Molecular genetic mechanism of sodium arsenite on growth and development 亚砷酸钠对生长发育影响的分子遗传机制研究
The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary ( CHO) cells is reported. 本文报告了亚砷酸钠和砷酸钠对中国地鼠卵巢细胞(CHO)的毒性和细胞遗传学效应。
Sodium arsenite down-regulated the expression of AP-1 and MIP-1 α and may have some therapeutic effects in RA. 亚砷酸能下调AP-1和MIP-1α表达,可能对RA有一定治疗作用。
This paper presents the results of studies on cytogenetic effects of sodium arsenite on mouse bone marrow cells. 本文报告了亚砷酸钠引起小鼠骨髓细胞的细胞遗传学效应。
Influence of Sodium Selenite on Sperm Abnormalities Induced by Sodium Arsenite in Mice 亚硒酸钠对亚砷酸钠所致的小鼠精子畸形的影响
Methods 30 healthy white rats were randomly allocated to an experimental group and a control group. The experimental group were given subcutaneous injection with 0.02mg/g sodium arsenite solution, and the control group were given subcutaneous injection with distilled water. 方法以健康大白鼠30只,随机分为实验组和对照组,实验组皮下注射亚砷酸钠溶液(0.02mg/g),正常组皮下注射蒸馏水。
An agglutination test on transformed cells induced by nickel sulfate and sodium arsenite 硫酸镍、亚砷酸钠所致转化细胞的凝集试验粘合剂中镍的测定
Trivalent arsenicals, including sodium arsenite and the more soluble arsenic trioxide, inhibit many enzymes by reacting with biological ligands that possess available sulfur groups. 三价的砷,包括亚砷酸钠及可溶性更高的As203可以通过与带有含硫基团的蛋白作用从而抑制体内很多种酶的活性。
In this study, the effects of sodium arsenite on cell division, growth and death in yeast were analyzed. 本文以酵母细胞为主要材料,研究了亚砷酸钠诱导细胞死亡的作用机制。
No synergy on Sodium selenite and Trisodium phosphate for arsenic exposure on liver cell proliferation. ( 2) Sodium selenite on sodium arsenite in mice liver and kidney lipid peroxidation damage has obvious protective effect. 亚硒酸钠对亚砷酸钠造成小鼠肝、肾的脂质过氧化损伤具有明显的保护作用,术见磷酸钠与亚硒酸钠联合应用对砷造成小鼠肝、肾的脂质过氧化损伤的协同效应。
Objective: To investigate the effects of sodium arsenite on lipid peroxidation and antioxidant in mice liver 、 kidney and brain; To explorer Glutathione S-transferase ( GST) activities and its genes expression, and to analyze the relationship between GST activities and the capacity of antioxidation. 目的:了解亚砷酸钠亚慢性染毒对小鼠不同脏器组织脂质过氧化水平及抗氧化作用,探讨亚砷酸钠对谷胱甘肽S-转移酶(GST)活力及其基因表达的影响,分析GST活力与抗氧化能力的相关性。